Effect of Methotrexate on osseointegration of implants?

A 60-year old female patient has been using Methotrexate 7.5mg daily for cancer treatment. She has been using this medication for quite a long time, of around 5 years. What are the ill effects of Methotrexate on osseointegration of implants? I have to rehabilitate maxillary arch with dental implants after extraction of existing teeth.

Editors Note:
While Methotrexate is used in high doses as a chemotherapy agent, and that is its original indication, in lower doses it is also widely used to treat psoriasis or rheumatoid arthritis. Methotrexate is in a class of medications called antimetabolites. See a detailed description at Medline. For a discussion of the the mechansim of action see Arthritis.org

Osseo News comments:

This question has been discussed before here. If you search for Methotrexate in the Cases section, you can find a few posts. Here are two links [Dental implant placement in patient taking methotrexate?](https://www.osseonews.com/dental-implant-placement-patient-taking-methotrexate/) and [Patient on Aledronic acid and Methotrexate: Risks of complications?](https://www.osseonews.com/patient-on-aledronic-acid-and-methotrexate-risks-of-complications/), hope that helps. Not sure if there is any new research on this topic.